Ketamine Research and News

Ketamine for depression is an evolving field, and we strive to stay current on related literature and scientific studies. We’ve organized a comprehensive set of sources below, including medical society consensus statements, key systematic reviews, academic publications, popular news articles, and more.

Ketamine infusion therapy and efficacy for depression (Systematic Reviews and Meta-Analyses)

• Maintenance ketamine treatment for depression: a systematic review of efficacy, safety, and tolerability, The Lancet 2023

• Ketamine for the treatment of major depression: a systematic review and meta-analysis, eClinicalMedicine, 2023

• The Role of Ketamine in the Treatment of Bipolar Depression, Brain Science 2023

• Ketamine Use in Child and Adolescent Psychiatry: Emerging Data in Treatment-Resistant Depression, Insights from Adults, and Future Directions, Current Psychiatry Reports 2023

• Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis, Journal of Affective Disorders 2021

Societal consensus statements

• Canadian Network for Mood and Anxiety Treatments (CANMAT) Update on Clinical Guidelines for Management of Major Depressive Disorder in Adults, Canadian Journal of Psychiatry 2024

• The Management of Major Depressive Disorder, Annals of Internal Medicine 2022

• Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression, American Journal of Psychiatry 2021

• A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders,  JAMA Psychiatry 2017

Ketamine infusion therapy and efficacy for depression (Recent Clinical Trials)

• Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression. New England Journal Of Medicine 2023

• Rapid neuroplasticity changes and response to intravenous ketamine: a randomized controlled trial in treatment-resistant depression, Translational Psychiatry 2023

• One-Year Outcomes Following Intravenous Ketamine Plus Digital Training Among Patients with Treatment-Resistant Depression, JAMA Network 2023

• Intravenous Ketamine for Late-Life Treatment-Resistant Depression, American Journal of Geriatric Psychiatry 2023

• Neurocognitive effects of subanesthetic serial ketamine infusions in treatment resistant depression, Journal of Affective Disorder 2023

Ketamine for other mental health and wellness issues

• Bipolar Disorder: Ketamine for bipolar depression: an updated systematic review, Therapeutic Advances in Psychopharmacology 2023

• PTSD: The Impact of Ketamine for Treatment of Post-Traumatic Stress Disorder: A Systematic Review With Meta-Analyses, Annals of Pharmacotherapy 2023

• Suicidal Thoughts: A meta-analysis of the effects of ketamine on suicidal ideation in depression patients, Translational Psychiatry 2024

• Anxiety Disorders: Ketamine treatment for refractory anxiety: A systematic review, British Journal of Clinical Psychopharmacology 2022

• Substance Abuse Disorder: Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review, Frontiers in Psychiatry 2018

• Pain disorders: Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management, Regional Anesthesia and Pain Medicine 2018

Ketamine in popular news

• The Harvard Gazette: Ketamine Matches 'Gold Standard' in Major Depression Trial

• The New Yorker: Ketamine Therapy Is Going Mainstream. Are We Ready?

• Elemental: Ketamine Is Revealing a New Understanding of Depression and the Brain

• The New York Times: I Was Paralyzed by Severe Depression. Then Came Ketamine